Co enzyme Q 10 (Co Q 10), or ubiquinone , is a fat soluble vitamin or vitamin like substance that is also a potent antioxidant. Trace amount of CoQ10 exist in a variety of foods, such as organ meats, soy oil, sardines, mackerel and peanuts. The body also has the ability to make CoQ10 from the amino acid tyrosine, but this is a complicated process that requires at least 8 Vitamins and several trace minerals to complete. A deficiency in any one of these nutrients can hinder the body’s natural production of CoQ10. Co enzymes as a group are cofactors essential for a large number of enzymatic reactions within the body. CoQ10 is the cofactor for at least three very important enzymes used within the mitochondria of the cell. Remember the mitochondria are essentially the battery or furnace of the cell, where the energy of the cell is produced. Mitochondrial enzymes are needed for the production of the high energy phosphate and adenosine triphosphate, upon which cellular function depends. As written in my earlier blogs, oxidative process occurs in mitochondria. Not only energy start here, but the dangerous by products, free radical are also created. As a strong antioxidant, CoQ10 is extremely important in helping neutralize free radicals; however, its most important function in this situation is to help create energy. CoQ10, which helps fuel human mitochondria, was first isolated from a beef heart mitochondria by Dr. Frederick Crane in 1957, in 1958, Dr. Karl Folkers and co workers at Merack, Inc. determined the exact chemical structure of CoQ10 and began synthesizing it. The Japanese then perfected the technology in the mid 1970’s and now able to produce large amounts of pure CoQ10. Not only the numerous investigators established the normal blood levels of CoQ10, they have identified what seems to be direct correlation between the severity of heart failure and the correlating depletion of CoQ10. Significantly decreased amounts of CoQ10 have been noted in periodontal diseases, cancer heart disease and diabetes. Deficient levels of CoQ10 have been most clearly established, however, in the blood levels of patients with congestive heart failure and cardiomyopathy. CoQ10 deficiency can be the result several conditions like a poor diet, impairment of the body’s ability to synthesize CoQ10 and/or the body’s excessive utilization of CoQ10.
Investigators in the early 1980’s began trials in which patients took CoQ10 supplements. Over the past many years, interest has continued to mount and numerous clinical studies have tested the results of CoQ10 in cardiomyopathy and congestive heart failure patients. No fewer than nine placebo-conbolled clinical trials have taken place around the world. Many international symposia have been held on the biomedical and clinical aspects of CoQ10, at which doctors and scientists from different countries presented more than five hundred papers. The largest of these international studies was the Italian multi center trial by Baggio & Associates, which involved 2664 patients with heart failure. In this particular study nearly 80 percent of the patients improved when they started taking CoQ10 and 54 percent of these patients had major improvements in three major symptom categories. Put simply, studies and real life examples show that CoQ10 is an enormous helpful supplement in treating patients with life threatening heart conditions.